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KMID : 0370019990130000017
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Chung-Ang Journal of Pharmacal Sciences
1999 Volume.13 No. 0 p.17 ~ p.22
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Antimicrobial Activity of Monovalent and Bivalent Quinolone Carboxylic Acid Derivatives
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Abstract
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The synthesized monovalent and bivalent ligand derivatives of enoxacin, norfloxacin, and pipemidic acid were evaluated for their antimicrobial activities, in vitro, against Escherichia coli (6-PE-4), Klebsiella pneumoniae (JYA 78314), Bacillus subtilis (74-51), Proteus vulgaris (78651), Staphylococcus aureus (CHA79110), and Pseudomonas aeruginosa (8765-1 P_2). Free carboxylic monovalent ligand derivatives (1-6) showed similar activities to their parent quinolone carboxylic acids (enoxacin, norfloxacin, and pipemidic acid) and pivaloyloxymethyl ester analogues (7-12) have a little stronger activities than free carboxylic monovalent ligand derivatives (1-6). Bivalent ligand phthalidyl esters derivatives (13-20) of oxalyl and malonyl analogues showed stroger activities than those of fumaryl and succinyl analogues.
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